产品名称
45567(17N4) Rabbit Monoclonal Antibody
别名
NF A2; Oct 2; Oct-2; OTF-2; OTF2; POU2F2;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P09086
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:100
注意事项
Oct-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
功能
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:
2904654, PubMed:
7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:
2901913, PubMed:
2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:
10480874).
