产品名称
SAE2 / UBA2 (9G12) Rabbit Monoclonal Antibody
别名
ARX; SAE2; UBA2; UBLE1B;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9UBT2
免疫原
A synthetic peptide of human UBA2
稀释度
WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 IP: 1:20
注意事项
SAE2 / UBA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention
功能
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
