产品名称
PGC1 beta (19E7) Rabbit Monoclonal Antibody
别名
PERC; PGC1; PPARGC1; Ppargc1b;
纯度
Affinity-chromatography
蛋白名称
PERC, PGC1, PGC1B, PPARGC1
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q86YN6
稀释度
WB 1:500~1:2000 IP 1:50
注意事项
PGC1 beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitous with higher expression in heart, brain and skeletal muscle.
功能
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non- oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
