产品名称
Epac1 (4J15) Rabbit Monoclonal Antibody
别名
CAMP-GEFI; EPAC; EPAC1; HSU79275; bcm910;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O95398
免疫原
A synthetic peptide of human Epac1
稀释度
WB: 1:1000-1:5000 IHC: 1:100
注意事项
Epac1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney
功能
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP- induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
