产品名称
LYRIC (10G11) Rabbit Monoclonal Antibody
别名
3D3; 3D3/LYRIC; AEG1; Astrocyte elevated gene 1; LYRIC; LYRIC/3D3; Metadherin; MTDH; Protein LYRIC;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q86UE4
免疫原
A synthetic peptide of human LYRIC/AEG1
稀释度
WB: 1:2000-1:10000 IHC: 1:50 ICC/IF: 1:100
注意事项
LYRIC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed with highest levels in muscle- dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
细胞定位
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cell junction, tight junction Nucleus, nucleolus. Cytoplasm, perinuclear region Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus.
功能
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
