产品名称
SMYD3 (18W9) Rabbit Monoclonal Antibody
别名
KMT3E; Smyd3; ZMYND1; ZNFN3A1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9H7B4
免疫原
A synthetic peptide of human SMYD3
稀释度
WB: 1:1000-1:2000 IHC: 1:20 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
SMYD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and hepatocellular carcinomas.
细胞定位
Cytoplasm. Nucleus. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
功能
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:
15235609, PubMed:
22419068). Also methylates 'Lys-5' of histone H4 (PubMed:
22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:
15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:
15235609).
