RM5573

JAK1 (9I2) Rabbit Monoclonal Antibody

JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; JTK3;

Affinity-chromatography

常规抗体

JAK1

JAK1A, JAK1B

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

3716

P23458

WB 1:500~1:2000

133kDa

Rabbit IgG

JAK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue

Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333).

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