Contributes to histone modification (PubMed:
19131338, PubMed:
19556245, PubMed:
19103755, PubMed:
20018852, PubMed:
16600877, PubMed:
16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:
16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:
19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:
18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:
19103755, PubMed:
20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:
21220120, PubMed:
22266653).
