RM5567

SF2 (5X2) Rabbit Monoclonal Antibody

ASF; ASF1; SF2; SF2p33; SRp30a; SRSF1; SFRS1;

Affinity-chromatography

常规抗体

SRSF1

ASF, SF2, SF2P33, SFRS1

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

6426

Q07955

A synthetic peptide of human SF2

WB: 1:2000 IHC: 1:50 ICC/IF: 1:20-1:100 FC: 1:20

28kDa

28kDa

Rabbit IgG

SF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm (PubMed:12215544, PubMed:20308322, PubMed:9420331, PubMed:24449914) Nuclear import is mediated via interaction with TNPO3 (PubMed:24449914).

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

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