产品名称
MMP2 (12D11) Rabbit Monoclonal Antibody
别名
CLG 4; CLG 4A; CLG4; CLG4A; Gelatinase A; Gelatinase alpha; Gelatinase neutrophil; MMP 2; MMP II; MMP2; MONA; PEX; TBE 1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P08253
免疫原
A synthetic peptide of human MMP2
稀释度
WB: 1:1000-1:5000 ICC/IF: 1:200 FC: 1:200-1:500
注意事项
MMP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate
细胞定位
[Isoform 1]: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes
功能
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial- nuclear stress signaling with activation of the pro-inflammatory NF- kappaB, NFAT and IRF transcriptional pathways.
