产品名称
TRPM7 (15L9) Rabbit Monoclonal Antibody
别名
ALSPDC; CHAK; CHAK1; LTrpC7; TRPM7;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q96QT4
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:100
注意事项
TRPM7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Membrane; Multi-pass membrane protein
功能
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
