产品名称
Huntingtin (2P4) Rabbit Monoclonal Antibody
别名
HD; HDH; HTT; Huntingtin; IT15; ZHD;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P42858
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:100~1:500 FC 1:100
注意事项
Huntingtin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation
细胞定位
[Huntingtin]: Cytoplasm. Nucleus. Early endosome. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase- independent manner (PubMed:15654337). Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion (PubMed:16476778)
功能
[Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.
