Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts (PubMed:
7760007, PubMed:
15496415, PubMed:
15048703, PubMed:
16352806, PubMed:
23169771, PubMed:
24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:
15048703, PubMed:
16352806, PubMed:
24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:
15294938, PubMed:
16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:
15496415, PubMed:
16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:
24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:
23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:
15496415, PubMed:
23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).
