产品名称
Apg12 (18O8) Rabbit Monoclonal Antibody
别名
APG12-like; APG12L; ATG12; Autophagy 12; FBR93; HAPG12;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O94817
免疫原
A synthetic peptide of human Apg12
稀释度
WB: 1:1000-1:5000 IHC: 1:50-1:200 ICC/IF: 1:50-1:200
注意事项
Apg12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=TECPR1 recruits the ATG12- ATG5 conjugate to the autolysosomal membrane
功能
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.
