产品名称
MYO10 Rabbit Polyclonal Antibody
蛋白名称
Unconventional myosin-X (Unconventional myosin-10)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9HD67
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HD67/entry
Mouse Swissprot No.
F8VQB6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/F8VQB6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941D3ZJP6
免疫原
Synthesized peptide derived from human protein . at AA range: 680-760
特异性
MYO10 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
myosin X(MYO10) Homo sapiens This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011],
细胞定位
Cytoplasm, cytosol . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasm, cytoskeleton . Cell projection, filopodium tip . Cytoplasm, cell cortex . Cell projection, filopodium membrane ; Peripheral membrane protein . May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.
信号通路
Fc gamma R-mediated phagocytosis;
功能
function:Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Plays a role in regions of dynamic actin.,similarity:Contains 1 FERM domain.,similarity:Contains 1 myosin head-like domain.,similarity:Contains 1 MyTH4 domain.,similarity:Contains 2 PH domains.,similarity:Contains 3 IQ domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
