RM5525

FADD (16T14) Rabbit Monoclonal Antibody

FADD protein; MORT1;

Affinity-chromatography

常规抗体

FADD {ECO:0000303|PubMed:7538907, ECO:0000312|HGNC:HGNC:3573}

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

8772

Q13158

A synthetic peptide of human FADD

WB: 1:1000-1:5000 IHC: 1:20-1:100 ICC/IF: 1:20-1:50 FC: 1:20 IP: 1:20-1:50

28kDa

23kDa

Rabbit IgG

FADD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors (PubMed:7538907, PubMed:23955153, PubMed:19118384, PubMed:20935634, PubMed:16762833, PubMed:24025841). The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation (PubMed:7538907, PubMed:19118384, PubMed:20935634, PubMed:16762833). Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon- mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225).

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