RM5520

RAP80 (2M13) Rabbit Monoclonal Antibody

BRCA1-A complex subunit RAP80; RAP80; Receptor associated protein 80; RIP110; Rxrip110; UIMC1; X2HRIP110;

Affinity-chromatography

常规抗体

UIMC1

RAP80, RXRIP110

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

51720

Q96RL1

A synthetic peptide of human RAP80

WB: 1:2000-1:10000 IHC: 1:50 ICC/IF: 1:20

80kDa

80kDa

Rabbit IgG

RAP80 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis.

Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)

Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

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