产品名称
USP22 (14R2) Rabbit Monoclonal Antibody
别名
Deubiquitinating enzyme 22; Ubiquitin carboxyl terminal hydrolase 22; Usp22; USP3L;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9UPT9
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
注意事项
USP22 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver
细胞定位
Nucleus {ECO:0000250|UniProtKB:Q5DU02}.
功能
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
