产品名称
GABARAPL2 (18Q14) Rabbit Monoclonal Antibody
别名
ATG8C; FLC3A; GABA(A) receptor-associated protein-like 2; Gabarapl2; Ganglioside expression factor 2; GATE16; GEF2; General protein transport factor p16;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P60520
免疫原
A synthetic peptide of human GABARAPL2
注意事项
GABARAPL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine
细胞定位
Cytoplasmic vesicle, autophagosome. Endoplasmic reticulum membrane. Golgi apparatus {ECO:0000250|UniProtKB:P60519}
功能
Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:
20418806, PubMed:
23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:
20418806, PubMed:
23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:
20418806, PubMed:
23209295).
