产品名称
ULK3 (3B16) Rabbit Monoclonal Antibody
别名
Serine/threonine-protein kinase ULK3; Ulk3; unc 51 like kinase 3 (C. elegans); Unc-51-like kinase 3;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q6PHR2
免疫原
A synthetic peptide of human ULK3
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:50 ICC/IF: 1:20-1:50 FC: 1:20
注意事项
ULK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord
细胞定位
Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence
功能
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
