产品名称
HSD11B1 (17P16) Rabbit Monoclonal Antibody
别名
11-DH; 11-beta-HSD1; HSD11B1; HSD11; HSD11L; 11 beta HSD1;
纯度
Affinity-chromatography
蛋白名称
HSD11, HSD11L, SDR26C1
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P28845
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
HSD11B1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed. Highest expression in liver.
细胞定位
Endoplasmic reticulum membrane; Single-pass type II membrane protein
功能
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (PubMed:
10497248). Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
