产品名称
HP1 gamma (8Y11) Rabbit Monoclonal Antibody
别名
Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein; CBX3; HP1 gamma;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q13185
免疫原
A synthetic peptide of human HP1 gamma
稀释度
WB: 1:1000 IHC: 1:20 FC: 1:20-1:100 IP: 1:20
注意事项
HP1 gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin May be associated with microtubules and mitotic poles during mitosis (Potential).
功能
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:
28167679).
