产品名称
Angiopoietin 2 (9P12) Rabbit Monoclonal Antibody
别名
AGPT 2; Agpt2; ANG2; Angiopoietin 2a; Angiopoietin 2B; Angiopoietin2; ANGPT 2; Angpt2; Tie2 ligand;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O15123
免疫原
A synthetic peptide of human Angiopoietin 2
稀释度
WB: 1:1000-1:5000 IHC: 1:50
注意事项
Angiopoietin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
功能
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
