产品名称
Dynamin 2 (15Y18) Rabbit Monoclonal Antibody
别名
CMT2M; CMTDI1; CMTDIB; DI CMTB; Dnm2; DYN II; DYN2; Dynamin II; Dynamin2; DynaminII; DYNII;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P50570
稀释度
WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:100
注意事项
Dynamin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction {ECO:0000250|UniProtKB:P39052}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P39052}. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Midbody. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:P39054}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P39054}; Peripheral membrane protein {ECO:0000250|UniProtKB:P39054}. Note=Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (By similarity) Microtubule-associated. Also found in the postsynaptic density of neuronal cells. Co-localizes with PIK3C3 and RAB5A to the nascent phagosome (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054}
功能
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:
33713620). Involved in cytokinesis (PubMed:
12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).
