产品名称
Zic1 (4R9) Rabbit Monoclonal Antibody
别名
ZIC; Zic protein member 1; Zinc finger protein 201; Zinc finger protein ZIC1; ZNF201;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q15915
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:120
注意事项
Zic1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.
细胞定位
Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.
功能
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
