产品名称
Caspr (4V9) Rabbit Monoclonal Antibody
别名
Caspr; Caspr1; CNTNAP; Cntnap1; Contactin associated protein 1; MHDNIV; NCP1; Neurexin-4; Nrxn4; p190; Paranodin;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P78357
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
Caspr Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis
细胞定位
Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:O54991}
功能
Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.
