产品名称
FOLR1 (8G10) Rabbit Monoclonal Antibody
别名
Adult folate binding protein; FBP; Folate receptor 1; Folate Receptor 1 Precursor; Folate receptor alpha; FOLR1; FR alpha; KB cells FBP;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P15328
免疫原
A synthetic peptide of human Folate Binding Protein
稀释度
WB: 1:1000-1:2000 IHC: 1:200
注意事项
FOLR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
细胞定位
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin- coated vesicle. Endosome. Apical cell membrane Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane
功能
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
