产品名称
Growth hormone receptor (16L4) Rabbit Monoclonal Antibody
别名
GH-binding protein; GHBP; GHR; Serum binding protein; Somatotropin receptor;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P10912
免疫原
A synthetic peptide of human Growth hormone receptor
稀释度
WB: 1:1000-1:5000 FC: 1:50 IP: 1:50
注意事项
Growth hormone receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver
细胞定位
Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non- degradative pathway. [Growth hormone-binding protein]: Secreted. Note=Complexed to a substantial fraction of circulating GH
功能
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
