产品名称
MEIS1 (2B12) Rabbit Monoclonal Antibody
别名
Homeo box protein Meis1; Leukemogenic homolog protein; MEIS 1; Meis homeo box 1; Meis1; Meis1 mouse homolog; MEIS1 protein;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
O00470
稀释度
WB 1:1000~1:5000 IP 1:50 FC 1:50
注意事项
MEIS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
功能
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
