产品名称
MOG Rabbit Polyclonal Antibody
蛋白名称
Myelin-oligodendrocyte glycoprotein
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q16653
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16653/entry
Mouse Swissprot No.
Q61885
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61885
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63345
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
MOG Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
组织表达
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
细胞定位
[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 5]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 6]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 7]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 8]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 9]: Cell membrane ; Single-pass type I membrane protein .
功能
alternative products:Additional isoforms seem to exist,caution:Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).,function:Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.,online information:Myelin oligodendrocyte glycoprotein entry,similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:May form homo- or heterodimers between the different isoforms.,tissue specificity:Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
