RM5345

Menin (16H14) Rabbit Monoclonal Antibody

MEA1; Men1; Menin; Multiple Endocrine Adenomatosis 1; Multiple Endocrine Neoplasia 1; SCG2; Suppressor Candidate Gene 2; Wermer syndrome; ZES;

Affinity-chromatography

常规抗体

MEN1

SCG2

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

4221

O00255

A synthetic peptide of human Menin

WB: 1:2000-1:10000 IHC: 1:20-1:100 ICC/IF: 1:50-1:200 IP: 1:20-1:50

68kDa

68kDa

Rabbit IgG

Menin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Ubiquitous.

Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

现货