RM5343

Bag3 (14T7) Rabbit Monoclonal Antibody

BAG 3; BAG family molecular chaperone regulator 3; Bag3; Bcl 2 binding protein; Bcl-2-binding protein Bis; BIS; CAIR 1; Docking protein CAIR 1; MFM6;

Affinity-chromatography

常规抗体

BAG3

BIS

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

9531

O95817

Recombinant protein of human Bag3

WB: 1:1000 FC: 1:20

80kDa

62kDa

Rabbit IgG

Bag3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Cytoplasm. Note=Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920)

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti- apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).

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