RM5341

MBD1 (3J6) Rabbit Monoclonal Antibody

CXXC 3; Mbd1; MECP1 COMPLEX; PCM1; RFT;

Affinity-chromatography

常规抗体

MBD1

CXXC3, PCM1

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

4152

Q9UIS9

WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:20

67kDa

Rabbit IgG

MBD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed..

Nucleus. Nucleus matrix. Nucleus speckle Chromosome Note=Nuclear, in a punctate pattern (PubMed:12711603). Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes (PubMed:10648624, PubMed:10454587).

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

现货