产品名称
FRS2 (6V10) Rabbit Monoclonal Antibody
别名
FGFR signaling adaptor SNT; FGFR substrate 2; FRS2; FRS2A; FRS2 alpha; SNT; SNT1; Suc 1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q8WU20
免疫原
Recombinant protein of human FRS2
稀释度
WB: 1:1000 FC: 1:20 IP: 1:20
注意事项
FRS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis
细胞定位
Endomembrane system. Note=Cytoplasmic, membrane- bound
功能
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
