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PI3 Kinase p85 alpha (4H15) Rabbit Monoclonal Antibody

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产品基本信息

产品货号
RM5315
产品名称
PI3 Kinase p85 alpha (4H15) Rabbit Monoclonal Antibody
别名
GRB1; p85 alpha; PI3-kinase subunit p85-alpha; PI3K; PI3K regulatory subunit alpha; Pik3r1; PtdIns 3 kinase p85 alpha;
纯度
Affinity-chromatography
类别
常规抗体
基因名称
PIK3R1
蛋白名称
GRB1
推荐应用
WB
反应种属
Human,Mouse,Rat
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Gene ID
5295
Human Swissprot No.
P27986
稀释度
WB 1:500~1:2000
预测分子量
84kDa
同种型
Rabbit IgG
注意事项
PI3 Kinase p85 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)
功能
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
期货
现货

Western blot analysis of PI3 Kinase p85 alpha expression in (1) K562 cell lysate; (2) Raw 264.7 cell lysate; (3) C6 cell lysate.

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