产品名称
Periostin (12N8) Rabbit Monoclonal Antibody
别名
Fasciclin-I like; OSF2; Periostin; Periostin osteoblast specific factor; PN; POSTN; RP11 412K4.1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q15063
免疫原
A synthetic peptide of human Periostin
稀释度
WB: 1:1000 IHC: 1:200 IP: 1:20
注意事项
Periostin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
细胞定位
Golgi apparatus {ECO:0000250|UniProtKB:Q62009}. Secreted Secreted, extracellular space, extracellular matrix Note=Colocalizes with BMP1 in the Golgi {ECO:0000250|UniProtKB:Q62009}
功能
Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:
12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
