RM5309

Atg16L1 (3X18) Rabbit Monoclonal Antibody

APG16 like 1; APG16L; APG16L beta; ATG16A; ATG16L; Atg16l1; IBD10; WD repeat domain 30; WDR30;

Affinity-chromatography

常规抗体

ATG16L1

APG16L

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

55054

Q676U5

Recombinant protein of human ATG16L1

WB: 1:1000-1:2000 IHC: 1:20-1:50

68kDa

68kDa

Rabbit IgG

Atg16L1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Recruited to omegasomes membranes by WIPI2 Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 Localizes also to discrete punctae along the ciliary axoneme {ECO:0000250|UniProtKB:Q8C0J2}

Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).

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