产品名称
Atg4C (9C1) Rabbit Monoclonal Antibody
别名
APG4C; ATG4C; cysteine endopeptidase; AUT like 1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q96DT6
免疫原
Recombinant protein of human ATG4C
稀释度
WB: 1:1000 IHC: 1:50 FC: 1:20
注意事项
Atg4C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
功能
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
