产品名称
Atg4B (3B12) Rabbit Monoclonal Antibody
别名
Cysteine protease ATG4B; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B;
纯度
Affinity-chromatography
蛋白名称
APG4B, AUTL1, KIAA0943
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9Y4P1
稀释度
WB 1:500~1:2000 FC 1:100
注意事项
Atg4B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
功能
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
