产品名称
MRP5 Rabbit Polyclonal Antibody
蛋白名称
Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O15440
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15440/entry
Mouse Swissprot No.
Q9R1X5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R1X5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9QYM0
免疫原
Synthesized peptide derived from human protein . at AA range: 470-550
特异性
MRP5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside
组织表达
[Isoform 3]: Predominant isoform in retinal pigment epithelium, bladder, and stomach. ; Ubiquitously expressed, but levels in brain and muscle are especially high (PubMed:9827529, PubMed:10438534, PubMed:15501592). All isoforms are equally expressed in retina (PubMed:17521428).
细胞定位
Basolateral cell membrane ; Multi-pass membrane protein . Golgi apparatus lumen . Endosome membrane . Cytoplasmic granule . Apical cell membrane ; Multi-pass membrane protein . In most cells, routes to the basolateral plasma membrane, but in the brain capillary endothelial cells that form the blood-brain barrier, resides in the apical membrane. .
功能
function:Acts as a multispecific organic anion pump which can transport nucleotide analogs.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
