产品名称
BNIP1 (4X10) Rabbit Monoclonal Antibody
别名
BCL2 adenovirus E1B 19kD interacting protein 1; BNIP1; Nip1; sec20; SEC20L; Transformation-related gene 8 protein; TRG8; Vesicle transport protein SEC20;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q12981
稀释度
WB 1:500~1:2000 IHC 1:50~1:200
注意事项
BNIP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.
细胞定位
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein. Note=Localization to the mitochondrion is regulated by RNF186.
功能
As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:
15272311). Plays also a role in apoptosis (PubMed:
7954800, PubMed:
15272311, PubMed:
23896122). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:
23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
