RM5297

CRYAB (9C10) Rabbit Monoclonal Antibody

AACRYA; Alpha B crystallin; Alpha-crystallin B chain; CRYA2; Cryab; Crystallin alpha B; CTPP2; Heat shock 20 kD like protein; HspB5;

Affinity-chromatography

常规抗体

CRYAB

CRYA2, HSPB5

WB

Human,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

1410

P02511

A synthetic peptide of human Alpha B Crystallin

WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 IP: 1:50

22kDa

20kDa

Rabbit IgG

CRYAB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373)

Cytoplasm. Nucleus Secreted. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326) Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059)

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

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