产品名称
DR5 (3Q11) Rabbit Monoclonal Antibody
别名
Death receptor 5; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9;
纯度
Affinity-chromatography
蛋白名称
DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O14763
免疫原
A synthetic peptide of human DR5
稀释度
WB: 1:1000 IHC: 1:200 IP: 1:20
注意事项
DR5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain
细胞定位
Membrane; Single-pass type I membrane protein.
功能
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:
10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
