RM5272

Claudin 1 (5F6) Rabbit Monoclonal Antibody

Claudin1; CLD1l;CLDN 1; ILVASC; SEMP1;

Affinity-chromatography

常规抗体

CLDN1

CLD1, SEMP1

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

9076

O95832

A synthetic peptide of human Claudin 1

WB: 1:1000 IHC: 1:200 ICC/IF: 1:500-1:1000 FC: 1:50 IP: 1:50

18kDa

23kDa

Rabbit IgG

Claudin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).

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