RM5268

EAAT2 (4R4) Rabbit Monoclonal Antibody

EAAT2; Slc1a2;

Affinity-chromatography

常规抗体

SLC1A2

EAAT2, GLT1

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

6506

P43004

WB 1:500~1:2000 IP 1:50

62kDa

Rabbit IgG

EAAT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cell membrane; Multi-pass membrane protein

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).

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