产品名称
Annexin A2 (5A11) Rabbit Monoclonal Antibody
别名
Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; PAP-IV; Protein I; p36; ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; Annexin2; HEL S 270;
纯度
Affinity-chromatography
蛋白名称
ANX2, ANX2L4, CAL1H, LPC2D
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P07355
免疫原
A synthetic peptide of human Annexin A2
稀释度
WB: 1:1000 IHC: 1:20 ICC/IF: 1:50 FC: 1:20
注意事项
Annexin A2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism
功能
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:
18799458, PubMed:
24808179, PubMed:
22848640).