产品名称
GDNF (3J8) Rabbit Monoclonal Antibody
别名
ATF1; ATF2; gdnf; HFB1 GDNF; hGDNF; HSCR3;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P39905
稀释度
WB 1:500~1:2000 FC 1:50
注意事项
GDNF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change
功能
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.
