RM5249

S100 (1E16) Rabbit Monoclonal Antibody

Bpb; NEF; Protein S100-A1; S100 beta; S100 calcium binding protein A1; S100A; S100B; 100beta;

Affinity-chromatography

常规抗体

S100A1

S100A

WB

Human,Mouse

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

6271

P23297

WB 1:500~1:1000 IHC 1:100~1:500 IP 1:50 FC 1:50

11kDa

Rabbit IgG

S100 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Highly prevalent in heart (PubMed:12804600, PubMed:1384693). Also found in lesser quantities in skeletal muscle and brain (PubMed:1384693).

Cytoplasm. Sarcoplasmic reticulum. Mitochondrion {ECO:0000250|UniProtKB:P56565}

Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).

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