产品名称
PROX1 (11X14) Rabbit Monoclonal Antibody
别名
Homeobox prospero like protein; Prospero homeobox protein 1; prospero-related homeobox gene 1; PROX1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q92786
注意事项
PROX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
细胞定位
Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}
功能
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
