产品名称
CDHR5 Rabbit Polyclonal Antibody
基因名称
CDHR5 MUCDHL MUPCDH UNQ2781/PRO7168
蛋白名称
Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9HBB8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HBB8/entry
Mouse Swissprot No.
Q8VHF2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VHF2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JIK1
免疫原
Synthesized peptide derived from human protein . at AA range: 80-160
特异性
CDHR5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000; IF ICC 1:100-500;ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
cadherin related family member 5(CDHR5) Homo sapiens This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010],
组织表达
Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409).
细胞定位
Apical cell membrane ; Single-pass type I membrane protein . Cell projection, microvillus membrane ; Single-pass type I membrane protein .
功能
function:Acts as a calcium-dependent cell adhesion protein.,PTM:N- and O-glycosylated.,similarity:Contains 4 cadherin domains.,tissue specificity:Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
